Publications featuring Gram technology

Dec 2016

An electronic cigarette vaping machine for the characterization of aerosol delivery and composition

Christopher M. Havel, Neal L. Benowitz, Peyton Jacob III, Gideon St. Helen

Corresponding Author: Gideon St.Helen, PhD, Division of Clinical Pharmacology and Experimental Therapeutics, University of California, Box 1220, San Francisco, CA 94143-1220, USA. Telephone: 415-206-2687; E-mail: gideon.sthelen@ucsf.edu

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When we first contacted this esteemed research group at UCSF, we found that they had already created their own make-shift solution for producing smoke and vapor for research studies. Their piece-meal contraption seemed to work OK, but we identified significant margin for improvement in terms of consistency and reliability, which led us to design and build our own standardized laboratory vaping machine.

Unfortunately, the paper on Chris's old testing system was already written by the time our machine was ready for the spotlight, but we were still able add some valuable data. Researchers observed that the Gram vaping machine meets CORESTA standards for executing specific, square puff profiles. In contrast, researchers' old apparatus (with diaphragm pump) could not create the conditions specified under applicable testing standards.

The Gram vaping machine went on to be validated for use with tobacco cigarettes, under Health Canada Intensive and ISO testing conditions, and today is regularly used for generating smoke and vapor instead of the above-published solution.

June 2018

An Exploration of Smoking-to-Vaping Transition Attempts Using a “Smart” Electronic Nicotine Delivery System

Blank, M. L., Hoek, J., George, M., Gendall, P., Conner, T. S., Thrul, J., ... & Langlotz, T.

1University of Otago, Dunedin, New Zealand.
2Johns Hopkins University, Baltimore, MD.
3University of California San Francisco, San Francisco, CA.

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The first-ever study to use Gram's smart vaporizer.

Additional commentary coming soon.

Sept 2018

Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke

Nabavizadeh P1, Liu J1, Havel CM2, Ibrahim S3, Derakhshandeh R1, Jacob Iii P2,4, Springer ML1,3,4.

1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
2Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, San Francisco, California, USA.
3Division of Cardiology, University of California, San Francisco, San Francisco, California, USA.
4Center for Tobacco Control Research and Education, University of California, San Francisco, San Francisco, California, USA.

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The first study to examine the effects of Philip Morris' heat-not-burn IQOS product in a physiological animal model.

Additional commentary coming soon.

2019

Several completed studies in review

10+ publications coming in 2019